Services
Crystallization Screening:
- We set up 96-well crystallization screens using the Phoenix (Art Robbins) crystallization robot using a variety of screening reagents that have been developed specifically for protein and nucleic acid crystallization.
- We help the user analyze the results of this screening and design optimization experiments to produce large single diffraction quality crystals.
Data Collection and Processing:
- We teach the user to collect single crystal data sets on native or heavy atom substituted macromolecular crystals
- Users have access to HKL2000 or D*TREK to index, refine, integrate, and scale the single crystal data set
- Users have access to CCP4, SHELX, or SOLVE, to solve the structure by molecular replacement, or single or multiple isomorphous replacement, or in the case of synchrotron data, MAD (Multiple wavelength Anomalous Dispersion)
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