Curriculum Vitae
Updated: 10/25/02
Charles Williams Carter, Jr.
PERSONAL INFORMATION:
Business Address: 303 Faculty Laboratory Office Building CB# 7260
Department of Biochemistry
University of North Carolina
School of Medicine
Chapel Hill, NC 27599-7260
Business Telephone: (919) 966-3263
FAX: (919) 966-2852
Electronic mail: carter@med.unc.edu
Web page: http://hekto.med.unc.edu:8080/CARTER/Welcome.html
Home Address: 414 Westwood Drive
Chapel Hill, NC 27514
Home Telephone: (919) 942-6895
Date/Place of Birth: November 25, 1945
Montpelier, VT
EDUCATION:
Post-doctoral 1973-74, Structural Studies (A. Klug)
MRC Laboratory of Molecular Biology, Cambridge, UK
Post-doctoral 1972-73, Protein Crystallography (J. Kraut)
University of Calif., La Jolla, CA
Ph.D. 1972, Biology (J. Kraut)
University of Calif., San Diego, La Jolla CA
M.S. 1968, Chemistry
University of Calif., San Diego, La Jolla, CA
BA 1967, Molecular Biophysics, Cum Laude
Yale University, New Haven, CT
EMPLOYMENT HISTORY:
1989-present Professor of Biochemistry and Biophysics, University of North Carolina, School of Medicine, Chapel Hill, NC
1980-present Associate Professor of Biochemistry and Anatomy, University of North Carolina, School of Medicine, Chapel Hill, NC
1986-1987 Fogarty Senior International Fellow
Lure, France, Host: G. Bricogne.
1974-1980 Assistant Professor of Biochemistry and Anatomy, University of North Carolina, School of Medicine, Chapel Hill, NC
October 1973- American Cancer Society Postdoctoral Fellow,
October 1974: Medical Research Council Laboratory of Molecular Biology, Cambridge, England. Postdoctoral Mentor Dr. Aaron Klug.
June 1972 Postdoctoral Research Chemist, Department of
October 1973: Chemistry, University of California, San Diego, La Jolla, CA. Mentor Dr. Joseph Kraut.
September 1967 Graduate trainee, Department of Biology,
June 1972: University of California, San Diego, La Jolla, CA. Thesis Advisor Dr. Joseph Kraut.
MAJOR AREAS OF RESEARCH INTEREST:
X-Ray Crystallography. Protein stereochemistry and structural polymorphism in catalysis and recognition with emphasis on proteins from genetic and bioenergetic systems. Aminoacyl-tRNA Synthetases. Cytidine deaminases. Molecular evolution. Statistical designs for crystallization of macromolecules. Bayesian and other Direct phasing methods for macromolecular crystal structure determination. Applications of multivariate linear models in Bioinformatics.
PROFESSIONAL SOCIETIES:
1975-present American Crystallographic Association; President, 2002
1978-present The Biophysical Society
1979-present American Society of Biological Chemists
1992-present The Protein Society
GRANTS:
Current Support:
NIH NIGMS-48519 "TrptRNA Ligase: X-ray Studies of the Catalytic Cycle", P.I. 25% effort $683,260 direct costs for a four year period, 1 September, 2002 - 31 August, 2006.
NASA NAG1508 "Quantitative Multivariate Methods for Pre-Flight Optimization, and Post-Flight Evaluation of Macromolecular Crystal Growth". C. W. Carter, Jr., P.I. 12% Total direct costs: $492,534 1 March 1999 – 30 November 2002.
NSF ITR/ACS+IM 01-SC-NSF-1010 “Computional Geometry for Structural Biology”, Herbert Edelsbruner, Duke University Department of Computer Science, PI, Subacct Biochemistry and Biophysics, UNC-CH sub-acct # 5-47737, C. W. Carter, Jr., P.I. 10%. Total Direct Costs $107,964 for first year of five. September 2000 – August 2001.
Grants on which I am Co-Investigator, and which provide funds via sub-contracts:
NASA (Agency number unavailable) “In situ monitoring of biological materials using low-coherence interference sensors” Ben Ovryn, Division of Fluid Mechanics Lewis Space Flight Center, Cleveland, OH, P.I.
TEACHING:
Biochemistry 134: Case Studies in Structural Molecular Biology, Spring semester. 42 Hours. A Biochemistry and Biophysics core course. http://hekto.med.unc.edu:8080/CARTER/Bioch_134/Welcome.html
Biochemistry 144: Seminar on probabilistic formulations of the X-ray phase problem. Spring semester 1999 and alternate years 13 Hours. A discussion of the foundations and exploitation of Direct Methods. http://hekto.med.unc.edu:8080/CARTER/bayes/Welcome.html
Biochemistry xxx : Statistics: teasing insight from observations (offered fall 2002 as an informal tutorial jointly with Jeff roach)
COMMITTEES:
Departmental
Committee to review outgoing grant applications (Director; 1982-present)
Second-year graduate advisory committee (1998-Present)
UNC:
Advisory Committee, UNC Program in Cellular and Molecular Biophysics (2001-present)
Steering Committee, UNC Structural Molecular Biology Interest Group
Regional and National:
Panel Member: American Cancer Society Personnel B, January 1989 - June 1993. Ad hoc January 1995
Ad Hoc Member: NIH BBCA Study Section, February 1991.
Chair, NASA Review Panel, Crystal Growth and Microgravity, November, 1993
Chair, Site Visit Team, Science Definition Review and Requirements Definition Review, NASA, June 1995, July 1996
Program Chair, American Crystallographic Association Annual Meeting, Atlanta, August, 1994.
Co-Chair, Gordon Conference: Diffraction Methods in Molecular Biology, Andover, NH, June '96
Co-Organizer, Keystone Conference: Aminoacyl -tRNA Synthetases in Biology and Disease, Taos, NM 2-6 February '96
Elected to US National Committee for Crystallography for the term 1/96-12/98; 1/00-12/02.
Panel Member: American Cancer Society Tumor Biochemistry and Endocrinology, January 1996 - June 2001.
Panel Member: National Science Foundation Major Research Instrumentation Review April 1996-present.
NRC Space Studies Board, Committee on Microgravity Research 1997-present
University Space Research Agency Advisory Panel 1997 – Present
Ad Hoc panel member, NIH Physiological Chemistry Study Section, October 2000.
Reverse Site Visit, Bethesda, MD. February 2000. Yale Molecular Biophysics Program Project “Structural Biology of the Central Dogma”.
Reverse Site Visit, Bethesda, MD. November 2000. Hauptmann Woodward Institute Program Project “Direct Methods for Macromolecules”.
American Crystallographic Association Council (President 2002)
PUBLICATIONS:
Refereed Journals and Edited Volumes
1. Carter CW Jr, Freer ST, Xuong Ng H, Alden RA, Kraut J: Structure of the Iron-Sulfur Cluster in the Chromatium Iron Protein at 2.25A Resolution. Cold Spring Harbor Symp Quant Biol 36:381-385, 1971.
2. Carter CW Jr, Kraut J, Freer ST, Alden RA, Sieker LC, Adman E, Jensen LH: A Comparison of Fe4S4* Clusters in High Potential Iron Protein and in Ferredoxin. Proc Nat Acad Sci USA 69:3526-3529, 1972.
3. Carter CW Jr, Kraut J: A Proposed Model for Interaction of Polypeptides with RNA. Proc Nat Acad Sci USA 71:283-287, 1974.
4. Carter CW Jr, Kraut J, Freer ST, Xuong Ng H, Alden RA, Bartsch RG: 2.0A Crystal Structure of Oxidized Chromatium High Potential Iron Protein (HiPIP). J Biol Chem 249:4212-4225, 1974.
5. Carter CW Jr, Kraut J, Freer ST, Alden RA: Comparison of Redox Site Geometries in Oxidized and Reduced Chromatium High Potential Iron Protein (HiPIP) and in Ferredoxin. J Biol Chem 249:6339-6346, 1974.
6. Freer ST, Alden RA, Carter CW Jr, Kraut J: Crystallographic Refinement of Chromatium High Potential Iron Protein (HiPIP). J Biol Chem 250:46-54, 1975.
7. Carter CW Jr, Levinger L. F: Self-Redigestion of Native Chromatin. Biochem. Biophys Res Commun 74:955-960, 1977.
8. Carter CW Jr: New Stereochemical Analogies Between Iron-Sulfur Electron Transport Proteins. J Biol Chem 252:7802-7811, 1977.
9. Carter CW Jr: Histone Packing in the Nucleosome Core Particle of Chromatin. Proc Nat Acad Sci USA 75:3649-3653, 1978.
10. Levinger LF, Carter CW Jr, Kumaroo KK, Irvin JL: Cross-Referencing Testis Specific Nuclear Proteins by Two-Dimensional Gel Electrophoresis. (1978) J Biol Chem 253:5232-5234, 1978.
11. Shaw JE, Levinger LF, Carter CW Jr: Nucleosomal Organization of Epstein-Barr Virus DNA in Transformed Lymphoblastoid Cells. J Virol 29:657-665, 1979.
12. Levinger LF, Carter CW Jr: Superstructural Differences Between Chromatin in Nuclei and in Solution are Revealed by Kinetics of Micrococcal Nuclease Digestion. J Biol Chem 254:9477-9487, 1979.
13. Carter CW Jr, Carter CW: Protein Crystallization Using Incomplete Factorial Experiments. J Biol Chem, 254:12219-12223, 1979.
14. Carter CW, Levinger LF, Birinyi F: Dimeric Histone Interactions and Histone Packing. J Biol Chem, 255:748-754, 1980.
15. Sheridan RP, Allen LC, Carter CW Jr: Coupling Between Oxidation State and Hydrogen Bond Conformation in High Potential Iron Protein. J Biol Chem, 256:5052-5057, 1981.
16. Carter CW Jr, Green DC: Use of Chromatofocusing in Purification of Tryptophan tRNA Synthetase from B. Stearothermophilus. Anal Biochem. 124:327-332, 1983.
17. Coleman DE, Carter CW Jr: Crystals of Bacillus stearothermophilus Tryptophanyl-tRNA Synthetase Containing Enzymatically Formed Acyl Transfer Product TRP-ATP, An Active Site Marker for the 3'CCA Terminus of Trp-tRNAtrp. Biochemistry. 23:381-385, 1984.
18. Carter CW Jr, Coleman DE: Crystallization of Substrate and Product-Analog Complexes of Tryptophanyl-tRNA Synthetase from Bacillus stearothermophilus. Federation Proceedings. 43:2981-2983, 1984.
19. Carter CW Jr, Green DC, Toomim, CS, and Betts L: Two Step Purification of tRNAtrp from B. Stearothermophilus. Anal. Biochem. 151:515-519, 1985.
20. Baldwin, E.T., Crumley, K.V. and Carter, C.W. Jr.: "Practical, Rapid Screening of Protein Crystallization Conditions by Dynamic Light Scattering. Biophys. J. 49:47-48, 1986.
21. Rories, C.C.P., Carter, C.W. Jr: Sensitive Quantitation of Endonuclease Kinetics. J. Biochem. Biophys. Methods. 12:147-159, 1986.
22. Carter, C.W. Jr.: Cloning Heterologous Genes into Escherichia coli for Protein Production and Crystal Growth: Problems of Expression and Microheterogeneity. J. Cryst. Growth, 90:168-179, 1988.
23. Carter, C.W. Jr., Baldwin, E.T., and Frick, L.: Design of Statistical Experiments for Protein Crystal Growth and Use of a Precrystallization Assay. J. Cryst Growth, 90:60-73, 1988.
24. Betts, L., Frick, L., Wolfenden, R. and Carter, C.W. Jr.: Incomplete Factorial Search for Conditions Leading to High Quality Crystals of Escherichia coli Cytidine Deaminase Complexed to a Transition Stage Analogy Inhibitor. J. Biol. Chem., 264:6737-6740, 1989.
25. Carter, C.W., Jr., Crumley, K.V., Coleman, D.E., Hage, F., and Bricogne, G.: Direct Phase Determination for the Molecular Envelope of Bacillus stearothermophilus Tryptophanyl-tRNA Synthetase by X-ray Contrast Variation. Acta Crystallographica, A46:57-68, 1990.
26. Carter, C.W., Jr.: Efficient Factorial Designs and the Analysis of Macromolecular Crystal Growth Conditions. METHODS: A Companion to Methods in Enzymology, 1:12-24 .
27. Bell, J.B., Jones, M.E., and Carter, C.W., Jr.: Crystallization of Yeast Orotidine 5'-Monophosphate Decarboxylase Complexed with 1-(5'-Phospho-b-D-Ribofuranosyl) Barbituric Acid. Proteins, 9:143-151.1991.
28. Smith, F.R., Lattman, E.E., and Carter, C.W., Jr.: The Mutation b99 Asp-Tyr Stabilizes A New, Composite Quaternary Structure of Human Hemoglobin. Proteins 10:81-91, 1991.
29. Carter, C.W., Jr.: Design of Crystallization Experiments and Protocols. in Crystallization of Proteins and Nucleic Acids: A Practical Approach. A. Ducruix and R. Giegé, Eds., IRL Press, Oxford, 47-71, 1992.
30. Doublié, S and Carter, C.W., Jr: Preparation of Selenomethionyl Protein Crystals. in Crystallization of Proteins and Nucleic Acids: A Practical Approach. A. Ducruix and R. Giegé, Eds., IRL Press, Oxford, 311-317, 1992.
31. Xiang, S., Carter, C.W., Jr., Bricogne, G. and Gilmore, C.J: Entropy Maximization Constrained by Solvent Flatness: A New Method for Macromolecular Phase Extension and Map Improvement. Acta Cryst. D49:193-212, 1993.
32. Carter, C.W. Jr: Cognition, Mechanism, and Evolutionary Relationships in Aminoacyl-tRNA Synthetases. Annual Review of Biochemistry , 62: 715-748, 1993.
33. Betts, L., Xiang, S., Short, S. Wolfenden, R. and Carter, C.W., Jr: Cyridine Deaminase: 2.3 Å Crystal Structure of an Enzyme:Transition State Analog Complex. Journal of Molecular Biology. 235:635-656, 1994.
34. Carter, C. W. Jr., Doublié, S., and Coleman, D. E. Quantitative Analysis of Protein Crystal Growth: The TrpRS Crystal Polymorphism and its Relationship to Catalysis. Journal of Molecular Biology. 238:346-365, 1994.
35. Doublié, S., Xiang, S., Gilmore, C.J., Bricogne, G., and Carter, C.W., Jr.: Overcoming Non-Isomorphism by Phase Combination by Phase Permutation with Likelihood Scoring: Solution of the TrpRS Crystal Structure. Acta Crystallographica, A50:164-182 1994.
36. Doublié, S. and Carter, C.W., Jr.: Selenomethionyl Tryptophanyl-tRNA Synthetase: An Isomorphous Derivative and a Site-Directed Mutant. Submitted to Journal of Biological Chemistry. 1993.
37. Yin, Y. and Carter, C. W., Jr.: Quantitative Analysis in the Characterization and optimization of Protein Crystal Growth. Acta Crystallographica, Section D50, 572-590 1994
38. Carter, C. W. Jr.: "Entropy Maximization, Permutation, and Likelihood Scoring Methods for Improving Macromolecular Electron Density Maps" in Daresbury Study Weekend, "From the Initial Map to the Final Model", 1994
39. Carter, C.W., Jr.: The Nucleoside Deaminases for Cytidine and Adenosine: Structure, Transition State Stabilization, Mechanism, and Evolution. Biochimie, 77, 92-98, 1995.
40. Doublié, S., Gilmore, C.J., Bricogne, G. and Carter, C.W., Jr.: Tryptophanyl-tRNA synthetase crystal structure reveals an unexpected homology to tyrosyl-tRNA synthetase. STRUCTURE, 3:17-31 1995.
41. Carter, C.W., Jr.: Entropy, Likelihood and Phase Determination, STRUCTURE Ways and Means, STRUCTURE, 3:147-150, 1995.
42. Xiang, Shibin, Short, Steven A., Wolfenden, Richard, and Carter, Charles W., Jr.: Transition State Selectivity for a Single OH Group During Catalysis by Cytidine Deaminase. Biochemistry, 34:4516-4523, 1995.
43. Carter, C.W., Jr.: Solving Macromolecular Crystal Structures Using the Bayesian Paradigm, in Likelihood and Bayesian Inference and their Application to the Solution of New Structures. ACA Transactions, ed by Gérard Bricogne, American Crystallographic Association, , 1996.
44. Xiang, Shibin and Carter, C.W., Jr. Representing Stereochemical Information in Macromolecular Electron Density Distributions by Multi-dimensional Histograms. Acta Crystallographica D52:49-56 1996
45. Sever, Sanja, Rogers, Kelley, Rogers, M. John, Carter, Charles W., Jr., and Söll, Dieter, "Escherichia coli tryptophanyl-tRNA synthetase mutants selected for tryptophan auxotrophy implicate the dimer interface in optimizing amino acid binding" Biochemistry, 35:32-40:1996.
46. Xiang, Shibin, Short, Steven A., Wolfenden, Richard, and Carter, Charles W. Jr,: Cytidine Deaminase Complexed to 3-Deazacytidine" A "Valence-Buffer in Zinc Enzyme Catalysis" Biochemistry, 35:1335-1341, 1996.
47. Yin, Yuhui. and Carter, Charles W., Jr.: "Incomplete Factorial and Response Surface Methods in Experimental Design: Yield Optimization of tRNATrp from in vitro T7 RNA Polymerase Transcription" Nucl. Acids. Res. 24, 1279-1287 1996.
48. Carter, C. W., Jr.: "A Local Approximation to Supersaturation Affords a Useful Coordinate Transformation for the Study of Crystal Growth", Acta Crystallographica, D52:647-654 1996.
49. Hogue, Christopher W.V., Doublié, Sylvie, Xue, Hong, Wong, Jeffery Tse-Fei, Carter, Charles W., Jr., and Szabo, Arthur G.: "A concerted trptophanyl-adenylate dependent conformational change in B. subtilis tryptophanyl-tRNA synthetase revealed by the flourescence of tryptophan-92" J. Mol. Biol. 260:446-466, 1996.
50. Kuyper, Lee and Carter, Charles W., Jr.: "Resolving Crystal Polymorphisms by finding "Stationary Points" from Quantitative Analysis of Crystal Growth Response Surfaces", J. Cryst. Growth, 168:155-169, 1996.
51. Xiang, S., Short, S. A., Wolfenden, R. & Carter, C. W. J. Structure of the Cytidine Deaminase:Product Complex Provides Evidence for Efficient Proton Transfer and Ground-state Destabilization. Biochemistry 36:4768-4774 1997.
52. Carter, C. W., Jr. Response Surface Methods for Optimizing and Improving Reproducibility of Crystal Growth. Methods in Enzymology 276:74-99 1997.
53. Carter, C. W., Jr. & Xiang, S. Phase Improvement Using Conditional Probability Methods: Maximum Entropy Solvent Flattening and Phase Permutation. Methods in Enzymology 277 79-109 1997.
54. Kakuta, Y., Pedersen, L. G. Carter, C. W. Jr., Negishi, M. and Pedersen, L. C. Crystal Structure of Estrogen Sulfotransferase. Nature Structural Biology, 4:904-908 1997.
55. Xue, Hong, Xue, Yilong, Doublié, Sylvie, and Carter, C.W., Jr., Chemical modifications of Bacillus subtilis tryptophanyl-tRNA synthetase. Biochem. Cell. Biol. 75:709-715, 1997.
56. Navaratnam, N., Fujino, T., Bayliss, J., Jarmuz, A., How, A., Richardson, N., Angelika, S., Battacharya, S., Carter, C. W., Jr. & Scott, J. E. coli Cytidine Deaminase Provides Molecular Model for ApoB RNA Editing: Implications for Asymmetric RNA Substrate Presentation and Evolution of C to U Editing. J. Mol. Biol. 275:695-714 1998.
57. Lewis, J. P., Carter, Charles W., Jr., Hermans, Jan, Pan, Wei, Lee, Tai-Sung, and Yang, Weitao, “Active Species for the Ground-State Complex of Cytidine Deaminase: A Linear-Scaling Quantum Mechanical Investigation” J. Am Chem. Soc. 120:5407-5410, 1998.
58. Scott, J., Navaratnam, N., and Carter, C. W., “Molecular modelling and the appolipoprotein B containing lipoproteins” Atherosclerosis, 141(suppl 1):S17-S24. 1998.
59. Scott, J., Navaratnam, N., and Carter, C. W., “Molecular modelling of the biosynthesis of the RNA-editing enyzme APOBEC-1, responsible for generating the alternative forms of appolipoprotein B” Experimental Physiology, 84:791-900. 1999.
60. Carlow, D. C., Carter, C. W., Jr., Mejlhede, N., Neuhard, J., and Wolfenden, R., “Cytidine Deaminases from B. subtilis and E. coli: Compensating Effects of Changing Zinc Coordination and Quaternary Structure” Biochemistry, 38:12258-12265. 1999.
61. Lahr, S. J., Broadwater, A. Carter, C. W., Jr., Collier, M. Hensley, L., Waldner, J., Pielak, G. J., and Edgell, M. H., “Patterned Library Analysis: A method of the quantitative assessment of hypotheses concerning the determinants of protein structure” Proc Nat. Acad. Sci., USA, 96:14860-14865. 1999.pdf
62. Ilyin , V., Temple, B., Hu, M., Li, G.-P., Yin, Y., Vachette, P., & Carter, C. W., Jr., “2.9Å Crystal Structure of Ligand-free Tryptophanyl-tRNA Synthetase: Domain Movements Fragment the Adenine Nucleotide Binding Site” Protein Science 9:218-231. 2000.pdf
63. Praetorius-Ibba, M., Stange-Thomann, N., Kitabatake, M., Ali, K., Söll, I., Carter, C. W., Jr., Ibba, M., and Söll, D., “Ancient Adaptation of the Active Site of Tryptophanyl-tRNA Synthetase for Tryptophan Binding”, Biochemistry, 39:13136-13143. 2000.pdf
64. Roach, J.M., Retailleau, P. and Carter, C. W., Jr. “Phase Determination via Sayre-type Equations with Anomalous Scattering”, Acta Crystallographica, A57:341-350, 2001.pdf
65. Carter, C. W., Jr., LeFebvre, B., Cammer, S. A., Tropsha, A. & Edgell, M. H. (2001). Four-body potentials reveal protein-specific correlations to stability changes caused by hydrophobic core mutations. Journal of Molecular Biology 311(4):625-638.pdf
66. Deerfield, D. W. II, Carter, C. W., Jr., and Pedersen, L. G. (2001) Models for Protein-Zinc Ion Binding Sites. II. The Catalytic Sites. Int. J. Quant. Chem. 83:150-165.pdf
67. Retailleau, P., Yin, Y., Hu, M., Roach, J. M., Bricogne, G., Vonrhein, C., Roversi, P., Blanc, E., Sweet, R. M., and Carter, C. W., Jr , (2001) “High Resolution Experimental Phases for Tryptophanyl-tRNA (TrpRS) Synthetase Complexed with Tryptophanyl-5’AMP”, Acta Crystallographica, D57, 1595-1608.pdf
68. Carter, Charles W., Jr., Tropsha, Alex, and Edgell, Marshall. (2002) “Energetics of Enzyme Stability”, Trends in Biotechnology, 20:2-3.pdf
69. Roach, J. M. and Carter, C. W., Jr. (2002) “Local Squaring Equations” Acta Crystallographica A58:215-220.pdf
70. Noonan, Ryan C., Carter, Charles W., Jr., and Badgassarian, Carey K. (2002) “Enzymatic conformational fluctuations along the reaction coordinate of cytidine deaminase”, Protein Science, 11:1424-1434.pdf
71. Carter, C. W., Jr., Ilyin, V., Yin, Y., Huang, X., and Retailleau, P. (2001) “Thre TrpRS Conformations Stabiltize a Dynamic, Dissociative Transition State” in Using Crystallography to Understand Enzyme Mechanisms, Transactions of the American Crystallographic Association, Inc. 35:19-36.
72. Carter, C. W., Jr., and Duax, William L. (2002) “Did tRNA Synthetase Classes Arise on Opposite Strands of the Same Gene?” Molecular Cell, 10:705-708.pdf
73. Retailleau, P., Huang, X. Yin, Y., Hu, M., Weinreb, V., Vachette, P., Vonrhein, C., Bricogne, G., Roversi, P., Ilyin, V., and Carter, C. W. Jr. (2002) “Interconversion of ATP binding and conformational free energies by Tryptophanyl-tRNA Synthetase: structures of ATP bound to open and closed, pre-transition-state conformations”, J. Mol. Biol., In press. pdf
Editorial Activities:
Methods, A Companion to Methods in Enzymology, Vol 1, No. 1. "Protein and Nucleic Acid Crystallization. Academic Press. August, 1990. Special Volume Editor.
METHODS IN ENZYMOLOGY Volumes 276 (January 1997) and 277 (September 1997). "Macromolecular Crystallography" co-editor with Robert M. Sweet.
METHODS IN ENZYMOLOGY A new volume updating volumes 276 and 277 is now in preparation for publication late in 2001 or early in 2002.
Non-Refereed Journals:
1. Carter CW Jr: Cradles for Molecular Evolution. New Scientist 65:784-787, 1975.
2. Carter CW Jr: Histone Dimers in the Nucleosome Core Particle. In Structural Aspects of Recognition and Assembly in Biological Macromolecules Proceedings of the Seventh Annual Katzir Katchalsky Conference, 689-704, 1980.
Book Chapters:
1. Carter CW Jr: "X-Ray Diffraction Studies on Chromatium High Potential Iron Protein and on Ferredoxin." Iron Sulfur Proteins Vol. III, W. Lovenberg, ed., Academic Press. Chapter VI, p. 157-203, 1977.
2. Carter, C.W. Jr., (1998) "Protein Structure." in Bioorganic Chemistry: Peptides and Proteins, Sidney M. Hecht, ed., Oxford University Press, Oxford, UK p. 153-223.
3. Carter, C.W., Jr., (1998) "Nucleoside Deaminases for Cyttidine and Adenosine: Comparison with Deaminases Acting on RNA". in Modification and Editing of RNA, H. Grosjean and R. Benne, eds., ASM Press, Washington, D.C., p. 363-375.
4. Carter, C.W., Jr. (1998) "The Solvent Contrast Variation Method". in Direct Methods for Solving Macromolecular Structures, S. Fortier, ed., Kluwer Academic Publishers, Dordrecht, Netherlands. p. 227-237.
5. Carter, C.W., Jr. (1998) "Solving a Heavy-Atom Substructure by Direct Methods". in Direct Methods for Solving Macromolecular Structures, S. Fortier, ed., Kluwer Academic Publishers, Dordrecht, Netherlands. p. 253-273.
6. Carter, C.W., Jr. (1998) "Ab Initio Determination of a Low Resolution Molecular Envelope by Direct Methods". in Direct Methods for Solving Macromolecular Structures, S. Fortier, ed., Kluwer Academic Publishers, Dordrecht, Netherlands. p. 413-419.
7. Carter, C. W., Jr. (1999) “Experimental design, quantitative analysis, and the cartography of crystal growth” in Crystallization of Nucleic Acids and Proteins, A Practical Approach, A. Ducruix and R. Giegé, eds., Oxford University Press, 75-120.
8. Berne, P. F., Doublié, S., and Carter, C. W., Jr. (1999) “Molecular Biology for Structural Biology” in Crystallization of Nucleic Acids and Proteins, A Practical Approach, A. Ducruix and R. Giegé, eds., Oxford University Press, 45-74.
9. Carter, C. W., Jr. (2001). High potential iron sulfur proteins. In Handbook of Metalloproteins (Messerschmidt, A., Huber, R., Poulos, T. & Wieghardt, K., eds.), Vol. I, pp. 602-609. John Wiley & Sons, Chichester.
Committee on Microgravity Research, Space Studies Board, “Microgravity Research in Support of Technologies for the Human Exploration and Development of Space and Planetary Bodies”, National Academy Press, Washington, DC. 2000.
Current Postdoctoral supervision:
Jeffrey M. Roach (1999 – present) Jeff is a mathematician. His work involves using convolutional equations in the extension and refinement of phases for high resolution X-ray crystal structure determination.
Maryna Kapustina (2002 – present) Maryna is a physicist, whose work involves using free-energy calculations derived from molecular dynamics to identify differences in the conformational energies of the different states of Tryptophanyl-tRNA synthetase.
Current Graduate supervision: (none currently)
REFEREE:
Acta Crystallographica
Biochemistry
Biophysical Journal
Journal of Applied Crystallography
Journal of Biological Chemistry
Journal of Crystal Growth
Journal of Molecular Biology
Proceedings of the National Academy of Sciences
Protein Science
Biochimica Biophysica Acta
Archives of Biochemistry and Biophysics
Science
Structure
Nature
Nature Structural Biology
ACADEMIC AND PROFESSIONAL HONORS:
Wohlenberg Science Prize Berkeley College, Yale University, 1967
American Cancer Society Postdoctoral Fellowship, 1973-1974
Jefferson-Pilot Fellow in Academic Medicine UNC Chapel Hill School of Medicine 1976-1980
Fogarty Senior International Fellowship (1986-1987) Fogarty Center, NIH
Elected to US National Committee for Crystallography for the term 1/96-12/98; 1/00-12/02
Elected Vice-President of the American Crystallographic Association, to a three year term on the ACA Council, to begin 1/01 as Vice-President, then as President, and finally as Past-President.